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Youngevity - Ultimate Gluco-Gel 240 Capsules Glucosamine Sulfate 500mg Joint Support (Ships Worldwide)
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Doctor's BEST - Doctor’s Best Fisetin with Novusetin, Non-GMO, Vegan, Gluten & Soy Free, 100 mg, 30 Count
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Zubair –
No change observed. Waste of money
marco –
es un antioxidante que permite o vectoriza la autofagia de células senescentes promoviendo el antienvejecimiento, tiene ademas efecto cognitivo positivo aun en edad avanzada, es un flavonoide de tipo senolitico (antianging) que proviene principalmente de fresas y manzanas, no se siente el efecto pero este seria a nivel celular, seria cosa de hacerse exámenes para comprobar el efecto antioxidante, por mi parte lo estuve tomando por varias semanas y me sentí bien
Krista and John –
I take over 20 supplements. I just started taking this one a little over a year ago. I haven’t been sick since. I usually get sick 2-3 times per year. I live in a household with my wife who is a grade school administrator and my grandchild. I am constantly bombarded with illness. I use this by taking 1 pill a day and have used it twice as a senolytic. To take as a senolytic I recommend using the Mayo clinics latest study on frailty which doses at 20mg per KG of body weight. For me that was a 2100mg dose. I took it in olive oil and Bioperine (black pepper extract) for increased absorption. I believe it worked to decrease senescent cells in my body. My endurance increased and my everyday aches and pains went away. During this year of no sickness I did catch something once. I felt extremely tired and was running a fever of 102 degrees. This started at 2pm and I swallowed an additional 2 fisetin tablets and another zinc pill around 6pm. I went to bed at midnight still feeling very sick and with the fever. I woke up the next day with absolutely no symptoms and not sick at all. This stuff helps your body fight off the common cold and the flu. I’m truly convinced. My wife has also taken this and she has stayed sick free as well. She caught a couple of colds but fought it off and didn’t stay sick for more than a day each time.
I have read a lot of articles on Fisetin as a senolytic and I would suggest anyone over the age of 40 to try it at least once. The Mayo clinic is just finishing up a clinical trial that looks promising. Please google and read as much as you can about this wonderful supplement. It’s a game changer.
Update 3/10/2020 – a couple of weeks ago I had another incident where I was feeling weak and coming down with something. I had a fever of 100. Took a few more fisetin and a zinc pill and the next day I was perfectly fine. My 22 year old step daughter and 18 month old grand daughter on the other hand have been sick again since my last post. I believe my combination of supplements makes me immune from catching the flu or cold. The fisetin is a very big part of it.
update 9/22/20 – still sick free since my last update.
Francesco –
Animal Data Shows Fisetin to be a Surprisingly Effective Senolytic
It is exciting to see animal data arrive for some of the potentially senolytic compounds that may turn out to destroy enough senescent cells in mammals to be worth using as first generation rejuvenation therapies. As a reminder, the accumulation of senescent cells is one of the causes of aging; countless cells become senescent every day in our bodies, but near all are destroyed. A tiny fraction linger to cause significant harm through the inflammatory signal molecules that they secrete. If these errant cells can be removed, then inflammatory diseases and numerous aspects of aging can be turned back to some degree. The results in mice stand head and shoulders above all of the other approaches to aging in terms of reliability and breadth of benefits.
Some senolytic compounds have been tested in animals, but a larger body of candidate senolytic drugs are presently only accompanied by cell study data. The ability to selectively destroy senescent cells in a petri dish does little more than indicate potential; there is a significant rate of failure in medical research and development for compounds with promising cell data, and any number of reasons as to why they may not work well enough in tissues or otherwise turn out to be infeasible for use in animals and humans. Fisetin was one such senolytic candidate with cell study data only, and I had not viewed it as a likely prospect. It is a flavonoid, and the one other well-known possibly senolytic flavonoid turned out not to be useful on its own – though it is helpful as a part of a combination treatment.
Given that, results from the recent animal study of fisetin noted here greatly exceed expectations, surprisingly so. Fisetin appears about as effective in mice as any of the current top senolytics, such as the chemotherapeutics dasatinib and navitoclax. Per the data in the open access paper below, dosing with fisetin destroys 25-50% of senescent cells depending on organ and method of measurement. The dose level is large in absolute terms, as one might expect for a flavonoid. For aged mice and a one-time treatment, the researchers used 100 mg/kg daily for five days. The usual approach to scale up estimated doses from mouse studies to initial human trials leads to 500 mg per day for five days for a 60kg human.
Given the wealth of new results emerging these days, it seems to me that people focused on self-experimentation, open human trials, and investigative mouse studies in this field should be moving to focus on combination therapies. Consider a combination of fisetin, dasatinib, quercetin, piperlongumine, and FOXO4-DRI – multiple different mechanisms to provoke apoptosis that are all hitting senescent cells at the same time. The goal would be to see if it is possible to engineer a significantly higher level of clearance of senescent cells than any of these senolytics can achieve on their own. This seems like a plausible goal, and may turn out to present meaningful competition to efforts such as those of Oisin Biotechnologies and other groups developing more sophisticated senolytic therapies that should have high rates of clearance.
Researchers Have Discovered How to Slow Aging
Quote:
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low-level inflammation and release enzymes that can degrade the tissue.
Researchers found a natural product, called fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. “These results suggest that we can extend the period of health, termed healthspan, even towards the end of life. But there are still many questions to address, including the right dosage, for example.” One question they can now answer, however, is why haven’t they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn’t have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.
Vander Modesto de Carvalho –
me atendeu as expectativas, tudo satisfatoriamente.